Rfk Gene Summary [Rat]
Riboflavin kinase (RFK; EC 2.7.1.26) is an essential enzyme that catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN), an obligatory step in vitamin B2 utilization and flavin cofactor synthesis (Karthikeyan et al., 2003 [PubMed 12623014]).[supplied by OMIM, Nov 2009]
Details
| Type | Protein Coding |
| Official Symbol | Rfk |
| Official Name | riboflavin kinase [Source:RGD Symbol;Acc:1549748] |
| Ensembl ID | ENSRNOG00000022273 |
| Bio databases IDs | |
| Aliases | riboflavin kinase |
| Synonyms | 0610038L10Rik, KOI-4, RGD1563242, riboflavin kinase, RIFK |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rfk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein binding
- riboflavin kinase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peripheral arterial disease
role in cell
- activation in
- apoptosis
- survival
- cell death
- recruitment in
- morphology
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rfk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- reactive oxygen species metabolic process
- FMN biosynthetic process
- flavin adenine dinucleotide biosynthetic process
- riboflavin biosynthetic process
- apoptotic process
- riboflavin metabolic process
- positive regulation of NAD(P)H oxidase activity
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- riboflavin kinase activity