Cybb

Predicted to enable several functions, including heme binding activity; nucleotide binding activity; and protein heterodimerization activity. Predicted to contribute to electron transfer activity. Involved in several processes, including cellular response to L-glutamine; cellular response to ethanol; and hypoxia-inducible factor-1alpha signaling pathway. Located in several cellular components, including neuronal cell body; nuclear envelope; and perinuclear endoplasmic reticulum. Part of NADPH oxidase complex. Biomarker of artery disease (multiple); end stage renal disease; primary hyperaldosteronism; and renal fibrosis. Human ortholog(s) of this gene implicated in X-linked chronic granulomatous disease; chronic granulomatous disease; and immunodeficiency 34. Orthologous to human CYBB (cytochrome b-245 beta chain). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cybb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Cybb gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Cybb gene, providing context for its role in the cell.