Plekhg5

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including endothelial cell chemotaxis; positive regulation of canonical NF-kappaB signal transduction; and regulation protein catabolic process at presynapse. Predicted to be located in cell-cell junction; cytoplasm; and lamellipodium. Predicted to be active in axon; endocytic vesicle; and plasma membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate C and autosomal recessive distal hereditary motor neuronopathy 4. Orthologous to human PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Plekhg5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Plekhg5 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Plekhg5 gene, providing context for its role in the cell.