Ahcyl1 Gene Summary [Rat]
Predicted to enable enzyme regulator activity and identical protein binding activity. Predicted to be involved in several processes, including S-adenosylmethionine cycle; angiotensin-activated signaling pathway; and mitochondrion-endoplasmic reticulum membrane tethering. Predicted to act upstream of or within several processes, including protein export from nucleus; regulation of mRNA 3'-end processing; and regulation of monoatomic ion transport. Located in apical plasma membrane and cytoplasm. Orthologous to human AHCYL1 (adenosylhomocysteinase like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ahcyl1 |
| Official Name | adenosylhomocysteinase-like 1 [Source:RGD Symbol;Acc:1309768] |
| Ensembl ID | ENSRNOG00000018569 |
| Bio databases IDs | |
| Aliases | adenosylhomocysteinase-like 1 |
| Synonyms | 1110034F20Rik, ACHYL1, adenosylhomocysteinase-like 1, Ahcy-rs3, DCAL, IRBIT, PPP1R78, PRO0233, S-adenosylhomocysteine hydrolase-like 1, XPVKONA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ahcyl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- S-adenosyl-L-homocysteine hydrolase, NAD binding domain
- S-adenosyl-L-homocysteine hydrolase
- adenosylhomocysteinase
- enzyme
- protein binding
- enzyme regulator activity
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- Alzheimer disease
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- uterine leiomyoma
- leiomyomatosis
role in cell
- apoptosis
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- soluble fraction
- endoplasmic reticulum mitochondria contact site
- intracellular membrane-bounded organelle
- Nucleus
- cytosol
- endoplasmic reticulum membrane
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ahcyl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- S-adenosylmethionine cycle
- response to calcium ion
- apoptotic process
- angiotensin-mediated signaling pathway
- positive regulation of sodium ion transport
- epithelial fluid transport
- regulation of mRNA 3'-end processing
- protein export from nucleus
- regulation of ion transmembrane transporter activity
- one-carbon metabolic process
- regulation of anion transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- cytoplasm
- cytosol
- ER-mitochondrion membrane contact site
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- RNA binding
- protein binding
- enzyme regulator activity
- adenosylhomocysteinase activity