Ckb Gene Summary [Rat]
Predicted to enable creatine kinase activity and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to estrogen stimulus; cellular response to wortmannin; and intracellular chloride ion homeostasis. Located in dendrite and neuronal cell body. Orthologous to human CKB (creatine kinase B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ckb |
| Official Name | creatine kinase B [Source:RGD Symbol;Acc:2357] |
| Ensembl ID | ENSRNOG00000010872 |
| Bio databases IDs | |
| Aliases | creatine kinase B |
| Synonyms | B-CK, Ck-3, CKBB, Ckbr, CPK-B, creatine kinase B, Creatine kinase b chain, creatine kinase, brain, Creatine kinase b type, Creatinine phosphokinase bb, HEL-211, HEL-S-29, KCRB |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ckb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- ubiquitin protein ligase binding
- Phosphagen (guanidino) kinases
- creatine kinase
- ATP:guanido phosphotransferase, N-terminal domain
- protein binding
- ATP:guanido phosphotransferase, C-terminal catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- epithelial cancer
- prostate cancer
- Huntington disease
- non-insulin-dependent diabetes mellitus
- endometriosis
- prostatic carcinoma
- gastric adenocarcinoma
- gastric epithelial cancer
- organismal death
role in cell
- apoptosis
- phosphorylation in
- cell viability
- migration
- phagocytosis by
- opening
- abnormal morphology
- doxorubicin resistance
- cell spreading
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- Extracellular Space
- Mitochondria
- cytosol
- apical membrane
- anchoring junction
- junctional complexes
- perikaryon
- dendrites
- cell-cell adherens junctions
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ckb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphocreatine biosynthetic process
- substantia nigra development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- mitochondrion
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- ubiquitin protein ligase binding
- creatine kinase activity