Mast3 Gene Summary [Rat]
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cytoskeleton organization and intracellular signal transduction. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 108. Orthologous to human MAST3 (microtubule associated serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mast3 |
| Official Name | microtubule associated serine/threonine kinase 3 [Source:RGD Symbol;Acc:1587639] |
| Ensembl ID | ENSRNOG00000022753 |
| Bio databases IDs | |
| Aliases | microtubule associated serine/threonine kinase 3 |
| Synonyms | DEE108, LOC684053, microtubule associated serine/threonine kinase 3, mKIAA0561 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mast3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- canonical PDZ domain
- protein binding
- Protein kinase domain
- PDZ domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Domain of unknown function (DUF1908)
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- developmental and epileptic encephalopathy type 108
- metabolic syndrome X
- primary biliary cirrhosis
- pervasive developmental disorder
- gout
- Huntington disease
- glioblastoma
- glioblastoma cancer
regulates
role in cell
- ciliogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mast3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- peptidyl-serine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein binding
- protein serine/threonine kinase activity