Lamp3 Gene Summary [Rat]
Predicted to be involved in several processes, including regulation of catabolic process; regulation of viral life cycle; and response to interferon-alpha. Predicted to act upstream of or within lipid metabolic process and surfactant homeostasis. Located in alveolar lamellar body membrane. Orthologous to human LAMP3 (lysosomal associated membrane protein 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lamp3 |
| Official Name | lysosomal-associated membrane protein 3 [Source:RGD Symbol;Acc:1307928] |
| Ensembl ID | ENSRNOG00000022792 |
| Bio databases IDs | |
| Aliases | lysosomal-associated membrane protein 3 |
| Synonyms | 1200002D17Rik, CD208, DC-LAMP, LAMP, LIMP1, lysosomal-associated membrane protein 3, TSC403 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lamp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysosome-associated membrane glycoprotein (Lamp)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- systemic lupus erythematosus
- psoriasis
- Parkinson disease
- preeclampsia
- ATAD3A-related type I interferonopathy
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- bipolar disorder
- lung adenocarcinoma
- lung adenocarcinoma formation
regulates
- lipid
- SFTP
role in cell
- apoptosis
- cell viability
- autophagy by
- invasive capability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cell surface
- perinuclear region
- inner membrane
- vesicles
- lysosome
- secretory granule membrane
- vesicle membrane
- lysosome membrane
- Weibel-Palade bodies
- early endosomes
- late endosomes
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lamp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- establishment of protein localization to organelle
- positive regulation of gene expression
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- regulation of autophagy
- adaptive immune response
- response to interferon-alpha
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- late endosome membrane
- early endosome
- perinuclear region of cytoplasm
- alveolar lamellar body membrane
- intracellular membrane-bounded organelle
- vesicle
- lysosomal membrane
- plasma membrane
- cell surface