LAMP3 Gene Summary [Human]
Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998 [PubMed 9768752]).[supplied by OMIM, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | LAMP3 |
| Official Name | lysosomal associated membrane protein 3 [Source:HGNC Symbol;Acc:HGNC:14582] |
| Ensembl ID | ENSG00000078081 |
| Bio databases IDs | |
| Aliases | lysosomal associated membrane protein 3 |
| Synonyms | 1200002D17Rik, CD208, DC-LAMP, LAMP, LIMP1, lysosomal-associated membrane protein 3, TSC403 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LAMP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysosome-associated membrane glycoprotein (Lamp)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- systemic lupus erythematosus
- psoriasis
- Parkinson disease
- preeclampsia
- ATAD3A-related type I interferonopathy
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- bipolar disorder
- lung adenocarcinoma
- lung adenocarcinoma formation
regulates
- lipid
- SFTP
role in cell
- apoptosis
- cell viability
- autophagy by
- invasive capability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cell surface
- perinuclear region
- inner membrane
- vesicles
- lysosome
- secretory granule membrane
- vesicle membrane
- lysosome membrane
- Weibel-Palade bodies
- early endosomes
- late endosomes
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LAMP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- establishment of protein localization to organelle
- positive regulation of gene expression
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- regulation of autophagy
- adaptive immune response
- response to interferon-alpha
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- late endosome membrane
- early endosome
- perinuclear region of cytoplasm
- alveolar lamellar body membrane
- intracellular membrane-bounded organelle
- vesicle
- lysosomal membrane
- plasma membrane
- cell surface