Pnldc1 Gene Summary [Rat]
Predicted to enable RNA binding activity and poly(A)-specific ribonuclease activity. Predicted to be involved in negative regulation of gene expression and spermatogenesis. Predicted to act upstream of or within blastocyst formation. Predicted to be active in endoplasmic reticulum and nucleus. Human ortholog(s) of this gene implicated in spermatogenic failure 57. Orthologous to human PNLDC1 (PARN like ribonuclease domain containing exonuclease 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pnldc1 |
| Official Name | PARN like, ribonuclease domain containing 1 [Source:RGD Symbol;Acc:1308678] |
| Ensembl ID | ENSRNOG00000023140 |
| Bio databases IDs | |
| Aliases | PARN like, ribonuclease domain containing 1 |
| Synonyms | Gm313, HsPNLDC1, PARN like ribonuclease domain containing exonuclease 1, poly(A)-specific ribonuclease (PARN)-like domain containing 1, SPGF57, Trimmer |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pnldc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- poly(A)-specific ribonuclease
- CAF1 family ribonuclease
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pnldc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- spermatogenesis
- blastocyst formation
- piRNA metabolic process
- nuclear-transcribed mRNA poly(A) tail shortening
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- poly(A)-specific ribonuclease activity
- 3'-5'-exoribonuclease activity
- RNA binding
- metal ion binding