Pnldc1 Gene Summary [Mouse]
Enables poly(A)-specific ribonuclease activity. Involved in nuclear-transcribed mRNA poly(A) tail shortening. Acts upstream of or within blastocyst formation. Located in endoplasmic reticulum. Is expressed in several structures, including early conceptus; gonad; and skin. Human ortholog(s) of this gene implicated in spermatogenic failure 57. Orthologous to human PNLDC1 (PARN like ribonuclease domain containing exonuclease 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Pnldc1 |
| Official Name | poly(A)-specific ribonuclease (PARN)-like domain containing 1 [Source:MGI Symbol;Acc:MGI:2685159] |
| Ensembl ID | ENSMUSG00000073460 |
| Bio databases IDs | |
| Aliases | poly(A)-specific ribonuclease (PARN)-like domain containing 1 |
| Synonyms | Gm313, HsPNLDC1, PARN like ribonuclease domain containing exonuclease 1, poly(A)-specific ribonuclease (PARN)-like domain containing 1, SPGF57, Trimmer |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pnldc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- poly(A)-specific ribonuclease
- CAF1 family ribonuclease
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pnldc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- spermatogenesis
- blastocyst formation
- piRNA metabolic process
- nuclear-transcribed mRNA poly(A) tail shortening
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- poly(A)-specific ribonuclease activity
- 3'-5'-exoribonuclease activity
- RNA binding
- metal ion binding