C1ql1 Gene Summary [Rat]
Predicted to enable signaling receptor binding activity. Predicted to be involved in regulation of synapse pruning. Predicted to act upstream of or within maintenance of synapse structure; motor learning; and neuron remodeling. Predicted to be located in climbing fiber; cytoplasm; and presynapse. Predicted to be active in cerebellar climbing fiber to Purkinje cell synapse and synaptic cleft. Orthologous to human C1QL1 (complement C1q like 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | C1ql1 |
| Official Name | complement C1q like 1 [Source:RGD Symbol;Acc:1306039] |
| Ensembl ID | ENSRNOG00000002963 |
| Bio databases IDs | |
| Aliases | complement C1q like 1 |
| Synonyms | Adil, C1QRF, C1QTNF14, complement C1q like 1, complement component 1, q subcomponent-like 1, CRF, CTRP14, gliacolin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat C1ql1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- receptor binding
- C1q domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
role in cell
- apoptosis
- autophagy in
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- Cytoplasm
- synaptic cleft
- presynaptic regions
- synapse
- presynaptic terminals
- excitatory synapses
- climbing fiber
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat C1ql1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- locomotory behavior
- neuron remodeling
Cellular Component
Where in the cell the gene product is active
- synaptic cleft
- cytoplasm
- collagen
- climbing fiber
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding