Als2 Gene Summary [Rat]
Predicted to enable several functions, including GTPase regulator activity; protein homodimerization activity; and small GTPase binding activity. Involved in several processes, including Rac protein signal transduction; in utero embryonic development; and regulation of endosome size. Located in several cellular components, including dendrite; growth cone; and neuronal cell body. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 2. Orthologous to human ALS2 (alsin Rho guanine nucleotide exchange factor ALS2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Als2 |
| Official Name | alsin Rho guanine nucleotide exchange factor ALS2 [Source:RGD Symbol;Acc:1310372] |
| Ensembl ID | ENSRNOG00000023280 |
| Bio databases IDs | |
| Aliases | alsin Rho guanine nucleotide exchange factor ALS2 |
| Synonyms | 3222402C23Rik, 9430073A21Rik, ALS2CR6, ALSIN, alsin Rho guanine nucleotide exchange factor, alsin Rho guanine nucleotide exchange factor ALS2, ALSJ, IAHSP, mKIAA1563, PLSJ |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Als2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Membrane Occupation and Recognition Nexus motif
- Regulator of chromosome condensation (RCC1) repeat
- MORN repeat
- VPS9p domain
- chromosome condensation 1-like domain
- enzyme binding
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
- identical protein binding
- RhoGEF domain
- protein kinase activator
- RhoGEF
- guanyl-nucleotide exchange factor
- Vacuolar sorting protein 9 (VPS9) domain
- protein homodimerization
- Dbl homology domain
Pathways
Biological processes and signaling networks where the Als2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infantile ascending hereditary spastic paralysis
- amyotrophic lateral sclerosis
- juvenile amyotrophic lateral sclerosis 2
- familial juvenile primary lateral sclerosis
- hereditary disorder
- ALS2-related spectrum disorder
- familial amyotrophic lateral sclerosis
- juvenile amyotrophic lateral sclerosis
- astrocytosis
- primary lateral sclerosis
role in cell
- apoptosis
- production in
- activation in
- number
- abnormal morphology
- cell death
- size
- activity
- outgrowth
- trafficking
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- soluble fraction
- membrane fraction
- insoluble fractions
- endosomal membrane fractions
- synaptosomal membrane fractions
- glutaminergic synapse
- ruffle
- perinuclear membrane
- perinuclear region
- cellular membrane
- Nucleus
- vesicles
- centrosome
- cytosol
- membrane ruffles
- dendritic spines
- growth cone
- recycling endosomes
- early endosomes
- perinuclear vesicles
- cell membrane leading edge
- perikaryon
- axons
- dendrites
- postsynaptic density
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Als2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Rac protein signal transduction
- endosome organization
- lysosomal transport
- protein localization
- protein homooligomerization
- neuron projection morphogenesis
- receptor recycling
- positive regulation of GTPase activity
- behavioral fear response
- neuromuscular junction development
- response to oxidative stress
- regulation of endosome size
- locomotory behavior
- positive regulation of protein kinase activity
- regulation of GTPase activity
- endosomal transport
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- growth cone
- dendrite
- nucleus
- early endosome
- centrosome
- cytoplasm
- intracellular membrane-bounded organelle
- dendritic spine
- ruffle
- cytosol
- vesicle
- macromolecular complex
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein serine/threonine kinase activator activity
- protein homodimerization activity
- guanyl-nucleotide exchange factor activity
- GTPase activator activity
- small GTPase binding