Rab5b Gene Summary [Rat]
Predicted to enable GDP binding activity; GTP-dependent protein binding activity; and GTPase activity. Predicted to be involved in several processes, including endocytosis; intracellular protein transport; and plasma membrane to endosome transport. Predicted to act upstream of or within endosome organization and regulation of endocytosis. Is active in synaptic vesicle membrane. Orthologous to human RAB5B (RAB5B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab5b |
| Official Name | RAB5B, member RAS oncogene family [Source:RGD Symbol;Acc:1306489] |
| Ensembl ID | ENSRNOG00000006130 |
| Bio databases IDs | |
| Aliases | RAB5B, member RAS oncogene family |
| Synonyms | C030027M18Rik, RAB5B, member RAS oncogene family, Rab5b predicted, Rabaptin5 β |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rab5b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP-dependent protein binding
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Rab5b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- Hutchinson-Gilford progeria syndrome
- rheumatoid arthritis
- insulin-dependent diabetes mellitus
- gastroesophageal reflux
- allergic asthma
- epithelial basal cell carcinoma
- asthma
- allergy
- atopic dermatitis
role in cell
- activation
- number
- formation
- migration
- fusion
- organization
- endocytosis by
- cross-presentation by
- size
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- synaptic vesicle membrane
- intracellular membrane-bounded organelle
- intracellular membranes
- cellular membrane
- Plasma Membrane
- endosomes
- vesicles
- secretory granule membrane
- cytosol
- endosomal membrane
- early endosomes
- endocytotic vesicle
- exosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rab5b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endosome organization
- antigen processing and presentation
- plasma membrane to endosome transport
- regulation of endocytosis
- endocytosis
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- early endosome membrane
- secretory granule membrane
- endocytic vesicle
- early endosome
- extracellular vesicular exosome
- endosome
- melanosome
- intracellular membrane-bounded organelle
- membrane
- endomembrane system
- synaptic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- small monomeric GTPase activity
- GDP binding
- GTP-dependent protein binding