Rab5c Gene Summary [Rat]
Predicted to enable GDP binding activity and GTPase activity. Predicted to be involved in endocytosis; intracellular protein transport; and plasma membrane to endosome transport. Predicted to act upstream of or within endosome organization and regulation of endocytosis. Is active in synaptic vesicle membrane. Orthologous to human RAB5C (RAB5C, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab5c |
| Official Name | RAB5C, member RAS oncogene family [Source:RGD Symbol;Acc:1307095] |
| Ensembl ID | ENSRNOG00000018568 |
| Bio databases IDs | |
| Aliases | RAB5C, member RAS oncogene family |
| Synonyms | L1880, RAB5CL, RAB5C, member RAS oncogene family, Rab5c predicted, RAB5L, RABL |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rab5c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- small GTP-binding protein domain
- GDP binding
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- Rab subfamily of small GTPases
- GTPase
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ras subfamily of RAS small GTPases
Pathways
Biological processes and signaling networks where the Rab5c gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypothyroidism
- coronary artery disease
- autoimmune disease
- acute graft-vs-host disease
- sickle cell anemia
- vitiligo
- autoimmune thyroid disease
- infection by vesicular stomatitis virus
- infection by murine hepatitis virus
role in cell
- binding in
- number
- formation
- binding
- size
- endocytosis by
- fusion
- autophagy
- autophagy in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- synaptic vesicle membrane
- exocytic vesicle
- cellular membrane
- Plasma Membrane
- endosomes
- vesicles
- Golgi Apparatus
- secretory granule membrane
- lipid droplets
- cytosol
- Golgi membrane
- lysosome membrane
- endosomal membrane
- early endosomes
- perinuclear vesicles
- endocytotic vesicle
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- pseudopodia
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rab5c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- plasma membrane to endosome transport
- intracellular protein transport
- endocytosis
Cellular Component
Where in the cell the gene product is active
- lipid particle
- early endosome membrane
- endosome
- extracellular vesicular exosome
- melanosome
- endomembrane system
- synaptic vesicle membrane
- azurophil granule membrane
- plasma membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- small monomeric GTPase activity
- GDP binding