Sp6 Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in epithelial to mesenchymal transition; odontogenesis; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of odontogenesis. Located in cytosol and nucleus. Used to study amelogenesis imperfecta. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1K. Orthologous to human SP6 (Sp6 transcription factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sp6 |
| Official Name | Sp6 transcription factor [Source:RGD Symbol;Acc:1306768] |
| Ensembl ID | ENSRNOG00000023551 |
| Bio databases IDs | |
| Aliases | Sp6 transcription factor |
| Synonyms | 1110025J03Rik, AI1K, EPFN, EPIPROFIN, KLF14, Sp6 transcription factor, trans-acting transcription factor 6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sp6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- Zinc-finger double domain
- SP6-9_N
- protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- microdontia
- prostate cancer
- syndactyly
- androgenic alopecia
- amelogenesis imperfecta type IK
- Alzheimer disease
- prostatic carcinoma
- oligodactyly
- pulmonary embolism
role in cell
- proliferation
- differentiation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sp6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of odontogenesis
- epithelial to mesenchymal transition
- odontogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity