Dlst Gene Summary [Rat]
Enables dihydrolipoyllysine-residue succinyltransferase activity; heat shock protein binding activity; and protein-folding chaperone binding activity. Involved in 2-oxoglutarate metabolic process and NADH metabolic process. Part of oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dlst |
| Official Name | dihydrolipoamide S-succinyltransferase [Source:RGD Symbol;Acc:1359615] |
| Ensembl ID | ENSRNOG00000005061 |
| Bio databases IDs | |
| Aliases | dihydrolipoamide S-succinyltransferase |
| Synonyms | 1600017E01Rik, 4632413C10Rik, 4930529O08Rik, dihydrolipoamide S-succinyltransferase, DLTS, E2K, Kdh E2, KGD2, ODO2, PGL7, PPGL7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dlst often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Biotinyl_lipoyl_domains
- dihydrolipoamide S-succinyltransferase
- sucB
- pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
- heat shock protein binding
- 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
- Biotin-requiring enzyme
- enzyme
- protein binding
- chaperone binding
- transferase, transferring acyl groups
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- urothelial bladder carcinoma
- transitional cell bladder cancer
- non-small cell lung carcinoma
- migraines
- Alzheimer disease
- hereditary paraganglioma-pheochromocytoma syndrome
- paraganglioma formation
- hereditary cancer-predisposing syndrome
- familial neoplasia
role in cell
- expression in
- growth
- cell death
- proliferation
- mitochondrial respiration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cellular membrane
- Nucleus
- Mitochondria
- cytosol
- mitochondrial matrix
- mitochondrial intermembrane space
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dlst gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- tricarboxylic acid cycle
- 2-oxoglutarate metabolic process
- succinyl-CoA metabolic process
- L-lysine catabolic process to acetyl-CoA via saccharopine
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- oxoglutarate dehydrogenase complex
- mitochondrion
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- dihydrolipoyllysine-residue succinyltransferase activity
- transferase activity, transferring acyl groups
- protein binding