Itm2b Gene Summary [Rat]
Predicted to enable ATP binding activity and amyloid-beta binding activity. Predicted to be involved in negative regulation of amyloid precursor protein biosynthetic process. Predicted to be located in Golgi-associated vesicle membrane and extracellular space. Predicted to be active in Golgi apparatus and plasma membrane. Human ortholog(s) of this gene implicated in ITM2B-related cerebral amyloid angiopathy 1 and ITM2B-related cerebral amyloid angiopathy 2. Orthologous to human ITM2B (integral membrane protein 2B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itm2b |
| Official Name | integral membrane protein 2B [Source:RGD Symbol;Acc:620727] |
| Ensembl ID | ENSRNOG00000016271 |
| Bio databases IDs | |
| Aliases | integral membrane protein 2B |
| Synonyms | ABRI, ADan, BRI, BRI2, BRICD2B, D14Sel6, E25B, E25BMM, E3-16, FBD, imBRI2, Integral Membrane Protein 2b, LOC100504588, RDGCA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Itm2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bcl-2 homology 3 domain
- ectodomain
- ATP binding
- protein binding
- BRICHOS domain
- beta-amyloid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- familial Danish dementia
- gliosis
- cerebral amyloid angiopathy
- amyloid vasculopathy
- endometriosis
- familial british dementia
- dystrophy
- synaptic dysfunction
- memory deficits
- cerebral microhemorrhage
role in cell
- cell death
- apoptosis
- formation
- molecular cleavage in
- long-term potentiation
- deposition
- deposition in
- lesioning
- area
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- Extracellular Space
- cellular membrane
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Itm2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nervous system development
- negative regulation of amyloid precursor protein biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- membrane
- Golgi-associated vesicle membrane
- endosome membrane
- Golgi apparatus
- Golgi membrane
- extracellular region
- organelle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- beta-amyloid binding