Kctd2 Gene Summary [Rat]

Predicted to enable cullin family protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KCTD2 (potassium channel tetramerization domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Kctd2
Official Name
potassium channel tetramerization domain containing 2 [Source:RGD Symbol;Acc:1566063]
Ensembl ID
ENSRNOG00000023764
Bio databases IDs NCBI: 498024 Ensembl: ENSRNOG00000023764
Aliases potassium channel tetramerization domain containing 2
Synonyms 2310012I15Rik, KIAA0176, LOC101928375, potassium channel tetramerisation domain containing 2, potassium channel tetramerization domain containing 2, RGD1566063
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kctd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • binding protein
  • Broad-Complex, Tramtrack and Bric a brac
  • BTB_POZ
  • protein binding
  • ion channel

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • epithelial cancer
  • liver cancer
  • hepatocellular carcinoma
  • bipolar disorder
regulated by
  • paclitaxel
  • U0126
  • G protein alpha
  • 2-amino-5-phosphonovaleric acid

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Unknown

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Kctd2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • proteasomal ubiquitin-dependent protein catabolic process
  • protein homooligomerization

Cellular Component

Where in the cell the gene product is active
  • cytoplasm
  • Cul3-RING ubiquitin ligase complex

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.