Fastkd2 Gene Summary [Rat]
Predicted to enable rRNA binding activity. Predicted to be involved in several processes, including mitochondrial gene expression; mitochondrial large ribosomal subunit assembly; and post-transcriptional regulation of gene expression. Predicted to be located in mitochondrial nucleoid. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 44. Orthologous to human FASTKD2 (FAST kinase domains 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fastkd2 |
| Official Name | FAST kinase domains 2 [Source:RGD Symbol;Acc:1307883] |
| Ensembl ID | ENSRNOG00000023923 |
| Bio databases IDs | |
| Aliases | FAST kinase domains 2 |
| Synonyms | 2810421I24Rik, COXPD44, FAST kinase domains 2, KIAA0971, RGD1307883 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fastkd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAST kinase-like protein, subdomain 1
- rRNA binding
- RNA-editing substrate-binding complex subunit 6 (RESC6) and related proteins
- protein binding
- PDDEXK family nucleases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribonucleoprotein granule
- Mitochondria
- mitochondrial matrix
- mitochondrial nucleoids
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fastkd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitochondrial mRNA stability
- positive regulation of mitochondrial translation
- apoptotic process
- mitochondrial translation
- RNA processing
- mitochondrial RNA processing
Cellular Component
Where in the cell the gene product is active
- ribonucleoprotein granule
- mitochondrial matrix
- mitochondrion
- mitochondrial nucleoid
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- rRNA binding