Prmt1 Gene Summary [Rat]
Enables several functions, including S-adenosyl-L-methionine binding activity; identical protein binding activity; and protein methyltransferase activity. Involved in several processes, including liver regeneration; positive regulation of erythrocyte differentiation; and positive regulation of hemoglobin biosynthetic process. Acts upstream of or within peptidyl-arginine methylation, to asymmetrical-dimethyl arginine. Located in cytosol. Part of protein-containing complex. Biomarker of asthma. Orthologous to human PRMT1 (protein arginine methyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prmt1 |
| Official Name | protein arginine methyltransferase 1 [Source:RGD Symbol;Acc:62020] |
| Ensembl ID | ENSRNOG00000026109 |
| Bio databases IDs | |
| Aliases | protein arginine methyltransferase 1 |
| Synonyms | 6720434D09Rik, ANM1, HCP1, Heterogeneous nuclear ribonucleoproteins methyltransferase like 2, heterogeneous ribonucleooproteins methyltransferase-like 2, Hnmt1l2, Hramt, HRMT1L2, IR1B4, Mrmt1, protein arginine methyltransferase 1, protein arginine N-methyltransferase 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prmt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- catalytic domain
- mitogen-activated protein kinase p38 binding
- enzyme binding
- enzyme
- AdoMet_MTases
- protein binding
- protein-arginine N-methyltransferase
- methyltransferase domain
- S-adenosylmethionine-dependent methyltransferase
- identical protein binding
- methyltransferase
- protein methyltransferase
- histone methyltransferase
- binding protein
- methyl-CpG binding
- snoRNP binding
- N-methyltransferase
Pathways
Biological processes and signaling networks where the Prmt1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- neoplasia
- squamous cell lung cancer
- lung squamous cell carcinoma
- colon cancer
- HER2 negative hormone receptor negative breast cancer
- organismal death
- hyperglycemia
- liver cirrhosis
role in cell
- expression in
- production in
- quantity
- growth
- phosphorylation in
- apoptosis
- trimethylation in
- proliferation
- damage in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- lysosome membrane
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prmt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to methionine
- RNA splicing
- positive regulation of translation
- neuron projection development
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
- positive regulation of cell proliferation
- protein homooligomerization
- positive regulation of hemoglobin biosynthetic process
- cell surface receptor signaling pathway
- regulation of megakaryocyte differentiation
- negative regulation of megakaryocyte differentiation
- response to DNA damage stimulus
- negative regulation of JNK cascade
- protein methylation
- positive regulation of erythrocyte differentiation
- cardiac muscle tissue development
- positive regulation of p38MAPK cascade
- viral protein processing
- chromatin remodeling
- in utero embryonic development
- regulation of BMP signaling pathway
- peptidyl-arginine methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- methylosome
- cytosol
- lysosomal membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein-arginine omega-N asymmetric methyltransferase activity
- identical protein binding
- N-methyltransferase activity
- protein methyltransferase activity
- protein-arginine omega-N monomethyltransferase activity
- methyltransferase activity
- methyl-CpG binding
- protein binding
- RNA binding
- mitogen-activated protein kinase p38 binding
- histone methyltransferase activity (H4-R3 specific)
- histone methyltransferase activity
- protein-arginine N-methyltransferase activity
- enzyme binding