Tmem237 Gene Summary [Rat]
Predicted to be involved in cilium assembly and regulation of Wnt signaling pathway. Predicted to be located in several cellular components, including microtubule cytoskeleton; nuclear speck; and photoreceptor cell cilium. Predicted to be active in ciliary transition zone. Human ortholog(s) of this gene implicated in Joubert syndrome and Joubert syndrome 14. Orthologous to human TMEM237 (transmembrane protein 237). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem237 |
| Official Name | transmembrane protein 237 [Source:RGD Symbol;Acc:1306705] |
| Ensembl ID | ENSRNOG00000024085 |
| Bio databases IDs | |
| Aliases | transmembrane protein 237 |
| Synonyms | AI853305, ALS2CR4, Gm972, JBTS14, transmembrane protein 237 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tmem237 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transmembrane protein 237
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- microtubule cytoskeleton
- ciliary transition zone
- cilia
- cellular membrane
- Plasma Membrane
- connecting cilia
- nuclear speckles
- photoreceptor outer segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tmem237 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- membrane
- ciliary transition zone
Molecular Function
What the gene product does at the molecular level
- protein binding