Lat

Predicted to enable molecular condensate scaffold activity; protein kinase binding activity; and signaling receptor complex adaptor activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; intracellular signaling cassette; and membrane raft distribution. Predicted to act upstream of or within gene expression and lymphocyte homeostasis. Predicted to be located in Golgi apparatus; cell-cell junction; and membrane. Predicted to be part of COP9 signalosome and TCR signalosome. Predicted to be active in immunological synapse. Human ortholog(s) of this gene implicated in immunodeficiency 52. Orthologous to human LAT (linker for activation of T cells). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lat often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Lat gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Lat gene, providing context for its role in the cell.