Poc1b Gene Summary [Rat]
Predicted to be involved in several processes, including organelle assembly; positive regulation of centriole elongation; and retina homeostasis. Predicted to act upstream of or within several processes, including homeostasis of number of cells; single fertilization; and spermatid development. Predicted to be located in centrosome and spindle pole. Predicted to be active in centriole and ciliary basal body. Human ortholog(s) of this gene implicated in cone-rod dystrophy 20. Orthologous to human POC1B (POC1 centriolar protein B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Poc1b |
| Official Name | POC1 centriolar protein B [Source:RGD Symbol;Acc:2323942] |
| Ensembl ID | ENSRNOG00000024450 |
| Bio databases IDs | |
| Aliases | POC1 centriolar protein B |
| Synonyms | 4933430F16Rik, CORD20, PIX1, POC1 centriolar protein B, TUWD12, WDR51B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Poc1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 4 WD40 domain
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
- NHL repeat unit of beta-propeller proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gallstone
- early-onset schizophrenia
- schizophrenia
- cone-rod dystrophy type 20
- retinal dystrophy
- myocardial infarction
- cholecystitis
- oligoasthenoteratozoospermia
- cone-rod dystrophy
role in cell
- proliferation
- formation
- motility
- assembly
- elongation
- formation in
- morphogenesis
- replication
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- basal bodies
- centrosome
- centriole
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Poc1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- retina homeostasis
- cilium morphogenesis
- centriole replication
Cellular Component
Where in the cell the gene product is active
- centrosome
- centriole
- cilium basal body
- cytoplasm
- spindle pole
Molecular Function
What the gene product does at the molecular level
- protein binding