Pfdn1 Gene Summary [Rat]
Predicted to enable amyloid-beta binding activity; protein folding chaperone; and unfolded protein binding activity. Predicted to be involved in negative regulation of amyloid fibril formation and protein folding. Predicted to act upstream of or within B cell activation; actin cytoskeleton organization; and brain development. Predicted to be part of prefoldin complex. Predicted to be active in centrosome and cytoplasm. Orthologous to human PFDN1 (prefoldin subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pfdn1 |
| Official Name | prefoldin subunit 1 [Source:RGD Symbol;Acc:1305603] |
| Ensembl ID | ENSRNOG00000018653 |
| Bio databases IDs | |
| Aliases | prefoldin subunit 1 |
| Synonyms | 2700086I23Rik, AU044714, PDF, PFD1, prefoldin 1, prefoldin subunit 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pfdn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prefoldin subunit
- prefoldin
- protein binding
- beta-amyloid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Alzheimer disease
- metastasis
- renal agenesis
- Parkinson disease
- hypertension
regulates
- cyclin A
- PFDN5
- agar
role in cell
- expression in
- migration
- growth
- cell viability
- activation
- organization
- epithelial-mesenchymal transition
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pfdn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chaperone-mediated protein folding
- protein folding
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- prefoldin complex
Molecular Function
What the gene product does at the molecular level
- protein binding involved in protein folding
- protein binding
- unfolded protein binding
- beta-amyloid binding