Kdm4c Gene Summary [Rat]
Enables chromatin binding activity. Involved in positive regulation of gene expression and positive regulation of neuron differentiation. Located in chromatin. Human ortholog(s) of this gene implicated in autistic disorder; breast cancer; carcinoma (multiple); head and neck cancer; and withdrawal disorder. Orthologous to human KDM4C (lysine demethylase 4C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kdm4c |
| Official Name | lysine demethylase 4C [Source:RGD Symbol;Acc:1307528] |
| Ensembl ID | ENSRNOG00000006644 |
| Bio databases IDs | |
| Aliases | lysine demethylase 4C |
| Synonyms | 2410141F18Rik, GASC1, JHDM3C, JMJD2C, LOC100912156, LOC108348059, lysine demethylase 4C, lysine (K)-specific demethylase 4C, TDRD14C |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kdm4c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- transcription co-activator
- jmjN domain
- Lamin-B receptor of TUDOR domain
- 2-oxoglutarate:oxygen oxidoreductase
- protein binding activity, bridging
- androgen receptor binding
- enzyme binding
- chromatin binding
- enzyme
- RmlC-like cupin superfamily
- PHD-finger
- PHD-like zinc-binding domain
- zinc ion binding
- PHD finger superfamily
- Tudor domain superfamily
- histone demethylase activity
- PHD-zinc-finger like domain
- Jumonji domain-containing protein 2A Tudor domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- systemic lupus erythematosus
- COVID-19
- tuberculosis
- schizophrenia
- periodontal pocket
- non-small cell lung cancer
- human immunodeficiency virus I infection
- primary antiphospholipid antibody syndrome
- vasculitis
role in cell
- expression in
- apoptosis
- proliferation
- transcription in
- growth
- migration
- invasion by
- differentiation
- cell viability
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- centromeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kdm4c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stem cell maintenance
- chromatin remodeling
- regulation of stem cell differentiation
- positive regulation of cell proliferation
- regulation of gene expression
- blastocyst formation
- androgen receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- regulation of androgen receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- centromeric heterochromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- androgen receptor binding
- ligand-dependent nuclear receptor transcription coactivator activity
- histone demethylase activity (H3-K9 specific)
- histone demethylase activity
- histone demethylase activity (H3-K36 specific)
- enzyme binding