Sdk2 Gene Summary [Rat]
Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules; retina morphogenesis in camera-type eye; and synapse assembly. Predicted to be located in membrane. Predicted to be active in synapse. Orthologous to human SDK2 (sidekick cell adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sdk2 |
| Official Name | sidekick cell adhesion molecule 2 [Source:RGD Symbol;Acc:1310397] |
| Ensembl ID | ENSRNOG00000024711 |
| Bio databases IDs | |
| Aliases | sidekick cell adhesion molecule 2 |
| Synonyms | 4632412F08RIK, 5330435L01RIK, FLJ10832, LOC100134174, LOC102556596, mKIAA1514, Sidekick 2, sidekick cell adhesion molecule 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sdk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FN3
- immunoglobulin domain
- Immunoglobulin like
- Purple acid Phosphatase, N-terminal domain
- Immunoglobulin I-set domain
- protein binding
- Fibronectin type 3 domain
- PDZ binding motif
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- panic disorder
- renal cancer
- clear cell sarcoma of the kidney
- soft tissue sarcoma cancer
- disorder of pregnancy
- COVID-19
- polymyositis
- hepatic fibrosis
- vertigo
- colorectal cancer
role in cell
- growth
- differentiation
- assembly
- adhesion
- arborization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sdk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synapse assembly
- retina layer formation
- camera-type eye photoreceptor cell differentiation
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding