Magi3 Gene Summary [Rat]
Enables protein phosphatase binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within positive regulation of JUN kinase activity. Predicted to be located in cell junction. Predicted to be active in cell-cell junction and cytoplasm. Orthologous to human MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Magi3 |
| Official Name | membrane associated guanylate kinase, WW and PDZ domain containing 3 [Source:RGD Symbol;Acc:621362] |
| Ensembl ID | ENSRNOG00000019885 |
| Bio databases IDs | |
| Aliases | membrane associated guanylate kinase, WW and PDZ domain containing 3 |
| Synonyms | 4732496O19Rik, 6530407C02Rik, dJ730K3.2, membrane associated guanylate kinase, WW and PDZ domain containing 3, mKIAA1634, Slipr |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Magi3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Domain present in PSD-95, Dlg, and ZO-1/2
- Domain with 2 conserved Trp (W) residues
- frizzled binding
- protein phosphatase binding
- WW
- WW class I binding domain
- canonical PDZ domain
- protein binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
- WW domain
Pathways
Biological processes and signaling networks where the Magi3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- neuroblastoma
- neuroblastoma formation
- survival
- hypothyroidism
- coronary artery disease
- Graves disease
- insulin-dependent diabetes mellitus
- autoimmune thyroid disease
- COVID-19
role in cell
- proliferation
- apoptosis
- activation in
- 5-fluorouracil sensitivity
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- intercellular junctions
- cell-cell contacts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Magi3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- apoptotic process
- GDP metabolic process
- GMP metabolic process
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- tight junction
- cell-cell junction
- cytoplasm
- membrane
- cell junction
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- guanylate kinase activity