Magi1 Gene Summary [Rat]
Predicted to enable alpha-actinin binding activity. Predicted to be involved in endothelial cell morphogenesis; positive regulation of cell-cell adhesion; and signal transduction. Predicted to be located in several cellular components, including adherens junction; nuclear lumen; and plasma membrane. Predicted to be active in cell-cell junction and cytoplasm. Orthologous to human MAGI1 (membrane associated guanylate kinase, WW and PDZ domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Magi1 |
| Official Name | membrane associated guanylate kinase, WW and PDZ domain containing 1 [Source:RGD Symbol;Acc:1586025] |
| Ensembl ID | ENSRNOG00000022060 |
| Bio databases IDs | |
| Aliases | membrane associated guanylate kinase, WW and PDZ domain containing 1 |
| Synonyms | AIP-3, BAIAP1, BAP-1, Gukmi1, Hs.476636, membrane associated guanylate kinase, WW and PDZ domain containing 1, mKIAA4129, TNRC19, WWP3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Magi1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- actinin binding
- canonical PDZ domain
- enzyme
- protein binding
- PDZ domain
- WW domain
- kinase
- Unstructured region on MAGI
- Domain with 2 conserved Trp (W) residues
- NK
- WW
- cpPDZ_Deg_HtrA-like
Pathways
Biological processes and signaling networks where the Magi1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- pulmonary embolism
- rheumatoid arthritis
- coronary artery disease
- Crohn disease
- asthma
- prostate cancer
- lung metastasis
- hepatitis A
- androgenic alopecia
role in cell
- expression in
- growth
- phosphorylation in
- migration
- invasion by
- signaling in
- formation
- formation in
- adhesion
- senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- Cytoplasm
- cell periphery
- cellular membrane
- Nucleus
- intercellular junctions
- apical membrane
- nucleoplasm
- nucleoli
- cellular protrusions
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Magi1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- signal transduction
- positive regulation of cell-cell adhesion
- cell surface receptor signaling pathway
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- adherens junction
- tight junction
- cell-cell junction
- cytoplasm
- cell junction
- nucleolus
- cell projection
- plasma membrane
- nucleoplasm
- cell periphery
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- alpha-actinin binding