Prtfdc1 Gene Summary [Rat]
Predicted to enable protein homodimerization activity. Predicted to be involved in IMP salvage and purine ribonucleoside salvage. Predicted to be active in cytosol. Orthologous to human PRTFDC1 (phosphoribosyl transferase domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prtfdc1 |
| Official Name | phosphoribosyl transferase domain containing 1 [Source:RGD Symbol;Acc:1310177] |
| Ensembl ID | ENSRNOG00000024874 |
| Bio databases IDs | |
| Aliases | phosphoribosyl transferase domain containing 1 |
| Synonyms | Gm13377, HHGP, phosphoribosyl transferase domain containing 1, phosphoribosyltransferase domain containing 1 pseudogene |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prtfdc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phosphoribosyl transferase domain
- protein homodimerization
- Phosphoribosyl transferase (PRT)-type I domain
- enzyme
- protein binding
- magnesium ion binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- post-traumatic stress disorder
- hypertension
- asthma
regulated by
- doxorubicin
- cyclosporin A
- cisplatin
- vancomycin
- puromycin aminonucleoside
- allopurinol
- gentamicin C
- triamterene
- lomustine
- phenylbutazone
role in cell
- apoptosis
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prtfdc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- guanine salvage
- purine ribonucleoside salvage
- GMP catabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- nucleotide binding
- protein binding
- protein homodimerization activity
- hypoxanthine phosphoribosyltransferase activity