Stat5a Gene Summary [Rat]
Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cell surface receptor signaling pathway via JAK-STAT; mammary gland development; and response to ethanol. Acts upstream of or within cellular response to cytokine stimulus. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human STAT5A (signal transducer and activator of transcription 5A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stat5a |
| Official Name | signal transducer and activator of transcription 5A [Source:RGD Symbol;Acc:3773] |
| Ensembl ID | ENSRNOG00000019496 |
| Bio databases IDs | |
| Aliases | signal transducer and activator of transcription 5A |
| Synonyms | pp95, signal transducer and activator of transcription 5A, Stat5 |
| Species | Rat, Rattus norvegicus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stat5a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- STAT protein, DNA binding domain
- nucleic acid binding
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- phosphate binding
- STAT protein, all-alpha domain
- DNA binding
- double-stranded DNA binding
- STAT_CCD
- Src homology 2 (SH2) domain
- transcription factor activity
- DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
- STAT protein, protein interaction domain
Pathways
Biological processes and signaling networks where the Stat5a gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- Angiopoietin Signaling
- Antioxidant Action of Vitamin C
- ErbB2-ErbB3 Signaling
- Estrogen-Dependent Breast Cancer Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Glucocorticoid Receptor Signaling
- Growth Hormone Signaling
- IL-2 Signaling
- IL-22 Signaling
- IL-3 Signaling
- IL-7 Signaling Pathway
- IL-9 Signaling
- JAK/Stat Signaling
- Oncostatin M Signaling
- PPAR Signaling
- Prolactin Signaling
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Role of JAK2 in Hormone-like Cytokine Signaling
- Role of Tissue Factor in Cancer
- TEC Kinase Signaling
- Th2 Pathway
- Thrombopoietin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- cytosolic fraction