Tnrc6b Gene Summary [Rat]
Predicted to enable RNA binding activity. Predicted to be involved in miRNA-mediated post-transcriptional gene silencing; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of with a positive effect on miRNA-mediated gene silencing by inhibition of translation. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. Human ortholog(s) of this gene implicated in subserous uterine fibroid and uterine fibroid. Orthologous to human TNRC6B (trinucleotide repeat containing adaptor 6B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnrc6b |
| Official Name | trinucleotide repeat containing adaptor 6B [Source:RGD Symbol;Acc:621428] |
| Ensembl ID | ENSRNOG00000024907 |
| Bio databases IDs | |
| Aliases | trinucleotide repeat containing adaptor 6B |
| Synonyms | 2700090M07RIK, A730065C02Rik, AI848765, Cbl27, D230019K20Rik, GDSBA, trinucleotide repeat containing 6b, trinucleotide repeat containing adaptor 6B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tnrc6b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- domain III
- TNRC6-PABC binding domain
- domain I
- protein binding
- Argonaute hook
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- esophageal squamous cell carcinoma
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- complex neurodevelopmental disorder
- uterine leiomyoma
- leiomyomatosis
- global developmental delay with speech and behavioral abnormalities
- prostatic carcinoma
- prostate cancer
regulates
- reporter mRNA
- PTEN
role in cell
- expression in
- proliferation
- migration
- invasion by
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tnrc6b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of translation involved in gene silencing by miRNA
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- gene silencing by miRNA
- gene silencing by RNA
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
Cellular Component
Where in the cell the gene product is active
- cytosol
- cytoplasmic mRNA processing body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding