Cpeb4 Gene Summary [Rat]
Predicted to enable several functions, including mRNA 3'-UTR binding activity; mRNA regulatory element binding translation repressor activity; and translation factor activity, RNA binding. Involved in several processes, including cellular response to glucose starvation; ionotropic glutamate receptor signaling pathway; and negative regulation of neuron apoptotic process. Located in cytoplasm; dendrite; and nucleus. Is active in postsynapse. Orthologous to human CPEB4 (cytoplasmic polyadenylation element binding protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cpeb4 |
| Official Name | cytoplasmic polyadenylation element binding protein 4 [Source:RGD Symbol;Acc:1311931] |
| Ensembl ID | ENSRNOG00000033169 |
| Bio databases IDs | |
| Aliases | cytoplasmic polyadenylation element binding protein 4 |
| Synonyms | CPE-BP4, cytoplasmic polyadenylation element binding protein 4, hCPEB-4, LOC685957, mCPEB-4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cpeb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- Cytoplasmic polyadenylation element-binding protein ZZ domain
- RNA recognition motif
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- Crohn disease
- atrial fibrillation
- poor social function
- gout
- inflammatory bowel disease
- peptic ulcer disease
- prion disease
- essential hypertension
role in cell
- apoptosis
- expression in
- growth
- cisplatin sensitivity
- abnormal morphology
- response by
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- postsynaptic region
- Nucleus
- Endoplasmic Reticulum
- synapse
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cpeb4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to amino acid stimulus
- response to ischemia
- negative regulation of cytoplasmic translation
- ionotropic glutamate receptor signaling pathway
- cellular response to glucose starvation
- translation
- negative regulation of neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- growth cone
- nucleus
- dendrite
- postsynaptic density
- perinuclear region of cytoplasm
- cytoplasm
- dendritic spine
- endoplasmic reticulum
- synapse
- neuron projection
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- metal ion binding
- ribosome binding
- translation repressor activity, nucleic acid binding
- translation factor activity, nucleic acid binding
- mRNA 3'-UTR binding