Stil Gene Summary [Rat]
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; positive regulation of cell cycle process; and protein localization to centrosome. Predicted to act upstream of or within several processes, including chordate embryonic development; embryonic organ development; and non-motile cilium assembly. Predicted to be located in cytosol; microtubule organizing center; and nucleoplasm. Predicted to be part of procentriole replication complex. Predicted to be active in microtubule organizing center. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 7. Orthologous to human STIL (STIL centriolar assembly protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stil |
| Official Name | STIL, centriolar assembly protein [Source:RGD Symbol;Acc:1304972] |
| Ensembl ID | ENSRNOG00000057760 |
| Bio databases IDs | |
| Aliases | STIL, centriolar assembly protein |
| Synonyms | MCPH7, Scl/Tal1 interrupting locus, SIL, STIL centriolar assembly protein, STIL, centriolar assembly protein |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stil often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SCL-interrupting locus protein N-terminus
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- autosomal recessive primary microcephaly type 7
- growth failure
- organismal death
- nonsyndromic cleft lip and palate
- behavioral deficit
- holoprosencephaly
- lung adenocarcinoma
- lung adenocarcinoma formation
- autosomal recessive primary microcephaly
role in cell
- apoptosis
- expression in
- proliferation
- migration
- accumulation in
- organization
- replication
- formation
- stabilization in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- daughter centriole
- Cytoplasm
- basal bodies
- centrosome
- centriole
- cytosol
- nucleoplasm
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stil gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- neural tube development
- positive regulation of G1/S transition of mitotic cell cycle
- mitotic spindle organization
- positive regulation of centriole replication
- smoothened signaling pathway
- regulation of centriole replication
- embryonic axis specification
- regulation of mitotic spindle organization
- determination of left/right symmetry
- forebrain development
- neural tube closure
- notochord development
- centrosome duplication
- in utero embryonic development
- negative regulation of apoptotic process
- heart looping
- floor plate development
- protein localization to centrosome
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- centriole
- cell cortex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding