Npat Gene Summary [Rat]
Predicted to enable transcription coactivator activity and transcription corepressor activity. Predicted to be involved in cell cycle G1/S phase transition and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in Cajal body; Gemini of Cajal bodies; and cytoplasm. Predicted to be active in nucleus. Orthologous to human NPAT (nuclear protein, coactivator of histone transcription). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Npat |
| Official Name | nuclear protein, co-activator of histone transcription [Source:RGD Symbol;Acc:1311947] |
| Ensembl ID | ENSRNOG00000024934 |
| Bio databases IDs | |
| Aliases | nuclear protein, co-activator of histone transcription |
| Synonyms | 6820401K01, BB112559, E14, E14/NPAT, nuclear protein, co-activator of histone transcription, nuclear protein in the AT region, p220, p220 NPAT |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Npat often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- transcription co-repressor
- Lissencephaly type1-like homology motif
- protein binding
- NPAT C terminus
- LisH
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Waldenström macroglobulinemia
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- adult T-cell leukemia/lymphoma
- renal clear cell adenocarcinoma
- renal clear cell cancer
- uterine leiomyoma
- leiomyomatosis
- silicosis
- refractive error
regulates
- histone H2B
- CDK9
- H2BC21
- DNA promoter
- DNA endogenous promoter
- histone H2A
- histone H4
- H4C3
- RNA polymerase II
- H1-5
role in cell
- cell cycle progression
- recruitment in
- transcription in
- S phase
- polyadenylation in
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nuclear foci
- nucleoplasm
- nuclear bodies
- Cajal bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Npat gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- in utero embryonic development
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- Cajal body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor activity
- protein binding
- transcription coactivator activity
- transcription corepressor activity