Sympk Gene Summary [Rat]
Predicted to be involved in mRNA processing. Predicted to be located in cytosol; nucleus; and plasma membrane. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human SYMPK (symplekin scaffold protein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sympk |
| Official Name | symplekin [Source:RGD Symbol;Acc:1306735] |
| Ensembl ID | ENSRNOG00000014353 |
| Bio databases IDs | |
| Aliases | symplekin |
| Synonyms | 1500016F02RIK, 4632415H16RIK, Hfn3g, Pta1, SPK, SYM, Symplekin, symplekin scaffold protein |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sympk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Symplekin tight junction protein C terminal
- protein binding
- Symplekin/PTA1 N-terminal
Pathways
Biological processes and signaling networks where the Sympk gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- non-insulin-dependent diabetes mellitus
- colon cancer
- colorectal cancer
- major depression
- gastroesophageal reflux
- cholelithiasis
- endometriosis
- Alzheimer disease
- hypertrophic cardiomyopathy
role in cell
- differentiation
- growth
- expression in
- cell viability
- transepithelial electrical resistance
- sphere formation
- tumorigenicity
- polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- ribonucleoprotein granule
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sympk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell adhesion
- mRNA processing
- negative regulation of protein binding
Cellular Component
Where in the cell the gene product is active
- nuclear stress granule
- tight junction
- nuclear body
- cytoskeleton
- cytoplasm
- mRNA cleavage and polyadenylation specificity factor complex
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding