Cdkn1b

Enables Hsp70 protein binding activity. Involved in several processes, including negative regulation of vascular associated smooth muscle cell proliferation; regulation of cyclin-dependent protein serine/threonine kinase activity; and response to genistein. Part of protein-containing complex. Used to study cataract; endocrine organ benign neoplasm (multiple); infertility; multiple endocrine neoplasia; and myocardial infarction. Biomarker of several diseases, including acute kidney failure; glomerulonephritis (multiple); obesity; pulmonary hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdkn1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Cdkn1b gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Cdkn1b gene, providing context for its role in the cell.