Lrrc8a Gene Summary [Rat]
Enables volume-sensitive anion channel activity. Involved in aspartate transmembrane transport; response to osmotic stress; and taurine transmembrane transport. Predicted to be located in cell surface and lysosomal membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 5. Orthologous to human LRRC8A (leucine rich repeat containing 8 VRAC subunit A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrrc8a |
| Official Name | leucine rich repeat containing 8 VRAC subunit A [Source:RGD Symbol;Acc:1311690] |
| Ensembl ID | ENSRNOG00000025296 |
| Bio databases IDs | |
| Aliases | leucine rich repeat containing 8 VRAC subunit A |
| Synonyms | AGM5, ebo, HsLRRC8A, leucine rich repeat containing 8A VRAC subunit A, leucine rich repeat containing 8 VRAC subunit A, LRRC8, mKIAA1437, SWELL1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lrrc8a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- volume-sensitive anion channel
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- protein binding
- organic anion transporter
- Pannexin-like TM region of LRRC8
- identical protein binding
- ion channel
- purine nucleotide transporter
- purine ribonucleotide transporter
- anion channel
- adenine nucleotide transporter
Pathways
Biological processes and signaling networks where the Lrrc8a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- reactive astrogliosis
- non-insulin-dependent diabetes mellitus
- hypothyroidism
- insulin resistance
- impaired glucose tolerance
- hypoplasia
- hydronephrosis
- hyperkeratosis
- agammaglobulinemia type 5
- paraparesis
role in cell
- apoptosis
- survival
- expression in
- differentiation
- phosphorylation in
- number
- fusion
- proliferation
- development
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lrrc8a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular glucose homeostasis
- pre-B cell differentiation
- spermatogenesis
- response to osmotic stress
- protein hexamerization
- positive regulation of myoblast differentiation
- positive regulation of insulin secretion
- anion transport
- taurine transport
- aspartate transport
- cell volume homeostasis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- ion channel complex
- lysosomal membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- anion channel activity
- volume-sensitive anion channel activity