Npm2 Gene Summary [Rat]
Enables enzyme binding activity and identical protein binding activity. Involved in positive regulation of DNA replication and positive regulation of catalytic activity. Predicted to be located in chromatin and nucleus. Predicted to be active in cytoplasm; nucleolus; and nucleoplasm. Orthologous to human NPM2 (nucleophosmin/nucleoplasmin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Npm2 |
| Official Name | nucleophosmin/nucleoplasmin 2 [Source:RGD Symbol;Acc:727816] |
| Ensembl ID | ENSRNOG00000025638 |
| Bio databases IDs | |
| Aliases | nucleophosmin/nucleoplasmin 2 |
| Synonyms | nucleophosmin/nucleoplasmin 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Npm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- k-rich motif
- enzyme binding
- Nucleoplasmin-like domain
- chromatin binding
- protein binding
- DNA dependent ATPase
- identical protein binding
Pathways
Biological processes and signaling networks where the Npm2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- primary prostate cancer
- metastatic prostate cancer
- sarcoidosis
role in cell
- size
- proliferation
- accumulation in
- remodeling
- abnormal morphology
- assembly
- mitosis
- meiosis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleolus-like body
- nucleolus precursor body
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Npm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of meiosis
- chromatin remodeling
- regulation of exit from mitosis
- blastocyst development
- positive regulation of DNA replication
- oocyte differentiation
- single fertilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA binding
- histone binding
- chromatin binding
- enzyme binding