NPM2 Gene Summary [Human]
Predicted to enable RNA binding activity; chromatin binding activity; and histone binding activity. Involved in several processes, including blastocyst development; oocyte differentiation; and regulation of cell cycle process. Located in chromatin and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NPM2 |
| Official Name | nucleophosmin/nucleoplasmin 2 [Source:HGNC Symbol;Acc:HGNC:7930] |
| Ensembl ID | ENSG00000158806 |
| Bio databases IDs | |
| Aliases | nucleophosmin/nucleoplasmin 2 |
| Synonyms | nucleophosmin/nucleoplasmin 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NPM2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- k-rich motif
- enzyme binding
- Nucleoplasmin-like domain
- chromatin binding
- protein binding
- DNA dependent ATPase
- identical protein binding
Pathways
Biological processes and signaling networks where the NPM2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- primary prostate cancer
- metastatic prostate cancer
- sarcoidosis
role in cell
- size
- proliferation
- accumulation in
- remodeling
- abnormal morphology
- assembly
- mitosis
- meiosis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleolus-like body
- nucleolus precursor body
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NPM2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of meiosis
- chromatin remodeling
- regulation of exit from mitosis
- blastocyst development
- positive regulation of DNA replication
- oocyte differentiation
- single fertilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA binding
- histone binding
- chromatin binding
- enzyme binding