Tex11 Gene Summary [Rat]
Predicted to be involved in meiotic gene conversion and meiotic nuclear division. Predicted to act upstream of or within several processes, including male gonad development; meiotic nuclear division; and negative regulation of apoptotic process. Predicted to be located in synaptonemal complex. Predicted to be active in central element. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 2. Orthologous to human TEX11 (testis expressed 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tex11 |
| Official Name | testis expressed 11 [Source:RGD Symbol;Acc:1560239] |
| Ensembl ID | ENSRNOG00000025672 |
| Bio databases IDs | |
| Aliases | testis expressed 11 |
| Synonyms | 4930565P14Rik, BB024231, MZIP4, RGD1560239, SPGFX2, Spo22, testis expressed 11, testis expressed gene 11, TGC1, TSGA3, ZIP4, ZIP4H |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tex11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Meiosis protein SPO22/ZIP4 like
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- colorectal cancer
- endometriosis
- male infertility
- prostatic carcinoma
- prostate cancer
- X-linked spermatogenic failure type 2
- nonobstructive azoospermia
- overall survival
- uterine leiomyoma
role in cell
- expression in
- apoptosis
- formation
- phosphorylation in
- proliferation
- binding in
- S phase
- meiosis
- segregation
- proliferative capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- synaptonemal complexes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tex11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male meiosis chromosome segregation
- germ cell programmed cell death
- reciprocal meiotic recombination
- male gonad development
- synaptonemal complex assembly
- resolution of meiotic recombination intermediates
- meiotic gene conversion
- fertilization
- negative regulation of developmental process
- chiasma assembly
- negative regulation of apoptotic process
- apoptotic process
- negative regulation of reproductive process
Cellular Component
Where in the cell the gene product is active
- central element
- chromosome
- synaptonemal complex
Molecular Function
What the gene product does at the molecular level
- protein binding