Hccs Gene Summary [Rat]
Predicted to enable heme binding activity and holocytochrome-c synthase activity. Predicted to be involved in cytochrome c-heme linkage. Predicted to be located in membrane. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 1 and microphthalmia. Orthologous to human HCCS (holocytochrome c synthase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hccs |
| Official Name | holocytochrome c synthase [Source:RGD Symbol;Acc:1563855] |
| Ensembl ID | ENSRNOG00000025910 |
| Bio databases IDs | |
| Aliases | holocytochrome c synthase |
| Synonyms | CCHL, holocytochrome c synthase, holocytochrome c synthetase, LSDMCA1, MCOPS7, MLS, RGD1563855 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hccs often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cytochrome c/c1 heme lyase
- enzyme
- protein binding
- heme binding
- holocytochrome-c synthase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cellular membrane
- Mitochondria
- cytosol
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hccs gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytochrome c-heme linkage
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- membrane
- mitochondrion
- cytosol
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- holocytochrome-c synthase activity
- heme binding