HCCS Gene Summary [Human]
The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | HCCS |
| Official Name | holocytochrome c synthase [Source:HGNC Symbol;Acc:HGNC:4837] |
| Ensembl ID | ENSG00000004961 |
| Bio databases IDs | |
| Aliases | holocytochrome c synthase, cytochrome c heme-lyase, holocytochrome-c synthetase |
| Synonyms | CCHL, holocytochrome c synthase, holocytochrome c synthetase, LSDMCA1, MCOPS7, MLS, RGD1563855 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HCCS often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cytochrome c/c1 heme lyase
- enzyme
- protein binding
- heme binding
- holocytochrome-c synthase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cellular membrane
- Mitochondria
- cytosol
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HCCS gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytochrome c-heme linkage
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- membrane
- mitochondrion
- cytosol
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- holocytochrome-c synthase activity
- heme binding