Mysm1 Gene Summary [Rat]
Predicted to enable deubiquitinase activity; histone binding activity; and transcription coactivator activity. Predicted to be involved in chromatin remodeling; positive regulation of transcription by RNA polymerase II; and regulation of hemopoiesis. Predicted to act upstream of or within pigmentation; regulation of cell migration; and regulation of hair follicle development. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in diabetic retinopathy. Orthologous to human MYSM1 (Myb like, SWIRM and MPN domains 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mysm1 |
| Official Name | myb-like, SWIRM and MPN domains 1 [Source:RGD Symbol;Acc:1311787] |
| Ensembl ID | ENSRNOG00000026299 |
| Bio databases IDs | |
| Aliases | myb-like, SWIRM and MPN domains 1 |
| Synonyms | 2A-DUB, BMFS4, C130067A03RIK, C530050H10Rik, LOC100047941, Myb like, SWIRM and MPN domains 1, RGD1311787 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mysm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SANT
- metallopeptidase
- histone binding
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- Mpr1p, Pad1p N-terminal (MPN) domains
- transcription co-activator
- Myb-like DNA-binding domain
- SWIRM domain
- enzyme
- protein binding
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Mysm1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic retinopathy
- bone marrow failure syndrome type 4
- transverse aortic constriction-induced cardiac hypertrophy
- diabetes mellitus
- cardiac hypertrophy
- anemia
- colorectal cancer
- exhaustion
role in cell
- apoptosis
- migration
- development
- number
- quantity
- function
- remodeling
- cycling
- ubiquitination in
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mysm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of hair follicle development
- chromatin remodeling
- pigmentation
- proteolysis
- positive regulation of transcription from RNA polymerase II promoter
- regulation of cell migration
- immune system process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- macromolecular complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- transcription coactivator activity
- metal ion binding
- histone binding