Cad Gene Summary [Rat]
Enables several functions, including aspartate carbamoyltransferase activity; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; and dihydroorotase activity. Involved in several processes, including alpha-amino acid metabolic process; cellular response to epidermal growth factor stimulus; and nucleobase-containing small molecule metabolic process. Located in neuronal cell body and terminal bouton. Part of protein-containing complex. Used to study hepatocellular carcinoma. Biomarker of hepatocellular carcinoma; renal cell carcinoma; and rhabdomyosarcoma. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 50. Orthologous to human CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cad |
| Official Name | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase [Source:RGD Symbol;Acc:1588606] |
| Ensembl ID | ENSRNOG00000026474 |
| Bio databases IDs | |
| Aliases | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase |
| Synonyms | 2410008J01Rik, Cad trifunctional, Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, Carbamoyl-p synthase/aspartate transcarbamylase/dihydroorotase, CDG1Z, Cpad, DEE50, EIEE50, GATD4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cad often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- MGS-like
- GMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit
- protein kinase
- Carbamoyl-phosphate synthase small chain, CPSase domain
- Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
- dihydroorotase, multifunctional complex type
- ATP binding
- KLF1_2_4_N
- enzyme
- pyrimidine nucleotide binding
- identical protein binding
- D-ala D-ala ligase C-terminus
- zinc ion binding
- Type 1 glutamine amidotransferase (GATase1)-like domain
- D-hydantoinase
- MGS-like domain
- carbamoyl-phosphate synthase, small subunit
- aspartate transcarbamoylase region
- nucleotide binding
- Glutamine amidotransferase class-I
- carbamoyl-phosphate synthase (glutamine-hydrolysing)
- ATP-grasp domain
- enzyme binding
- Carbamoyl-phosphate synthetase large chain, oligomerization domain
- protein binding
- metallo-dependent_hydrolases
- aspartate carbamoyltransferase
- carbamoyl-phosphate synthase, large subunit
- amino acid binding
- allantoinase
- carbamoyl-phosphate synthetase domain
- trpG/papA family
- dihydroorotase
- binding protein
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- Amidohydrolase family
- Carbamoyl-phosphate synthetase large chain, oligomerisation domain
- dihydroorotase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- adenoma formation
- hepatocellular carcinoma
- schizophrenia
- early infantile epileptic encephalopathy type 50
- bipolar disorder
- major depression
- lymphomagenesis
- X-linked subgroup of west syndrome
regulates
- uridine diphosphate
- pyrimidine base
- citrulline
- xenobiotic
- UTP
- glutamine
- pyrimidine
role in cell
- cell viability
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nuclear matrix
- cellular protrusions
- perikaryon
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cad gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to amine stimulus
- response to starvation
- glutamine metabolic process
- protein autophosphorylation
- female pregnancy
- lactation
- 'de novo' UMP biosynthetic process
- UDP biosynthetic process
- heart development
- UTP biosynthetic process
- 'de novo' pyrimidine base biosynthetic process
- response to insulin stimulus
- citrulline biosynthetic process
- liver development
- cellular response to epidermal growth factor stimulus
- xenobiotic metabolic process
- response to caffeine
- organ regeneration
- response to testosterone stimulus
- peptidyl-threonine phosphorylation
- response to cortisol stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- terminal button
- membrane
- nuclear matrix
- cytosol
- macromolecular complex
- neuronal cell body
- cell projection
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- aspartate carbamoyltransferase activity
- dihydroorotase activity
- carbamoyl-phosphate synthase (ammonia) activity
- protein kinase activity
- carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
- glutaminase activity
- ATP binding
- protein binding
- aspartate binding
- enzyme binding