Aph1b Gene Summary [Rat]
Predicted to enable endopeptidase activator activity and protein-macromolecule adaptor activity. Involved in locomotory behavior. Predicted to be located in membrane and transport vesicle. Predicted to be part of gamma-secretase complex. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human APH1B (aph-1 homolog B, gamma-secretase subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aph1b |
| Official Name | aph-1 homolog B, gamma secretase subunit [Source:RGD Symbol;Acc:1562468] |
| Ensembl ID | ENSRNOG00000027295 |
| Bio databases IDs | |
| Aliases | aph-1 homolog B, gamma secretase subunit |
| Synonyms | 0610008A10Rik, Aph1b, APH-1B', Aph1bl2, aph-1 homolog B, gamma secretase subunit, aph-1 homolog B, gamma secretase subunit like 2, aph-1 homolog B, γ secretase subunit, aph-1 homolog B, γ secretase subunit like 2, aph1 homolog C, gamma secretase subunit, aph1 homolog C, γ secretase subunit, LOC108348064, LOC681486, RGD1559979 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aph1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- protein binding activity, bridging
- enzyme regulator activity
- Aph-1 protein
- protease activator
Pathways
Biological processes and signaling networks where the Aph1b gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Docosahexaenoic Acid (DHA) Signaling
- Ephrin A Signaling
- ErbB4 Signaling
- Mitochondrial Dysfunction
- Molecular Mechanisms of Cancer
- Neuroinflammation Signaling Pathway
- Notch Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- APP
- transmembrane protein
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- transport vesicles