Nubpl Gene Summary [Rat]
Predicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly and mitochondrial respiratory chain complex I assembly. Predicted to be located in plasma membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 21. Orthologous to human NUBPL (NUBP iron-sulfur cluster assembly factor, mitochondrial). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nubpl |
| Official Name | nucleotide binding protein-like [Source:RGD Symbol;Acc:1307232] |
| Ensembl ID | ENSRNOG00000027444 |
| Bio databases IDs | |
| Aliases | nucleotide binding protein-like |
| Synonyms | 2410170E07Rik, C14orf127, HUIND1, IND1, MC1DN21, NUBP iron-sulfur cluster assembly factor like, NUBP iron-sulfur cluster assembly factor, mitochondrial, NUBP iron-sulphur cluster assembly factor like, NUBP iron-sulphur cluster assembly factor, mitochondrial, nucleotide binding protein-like, RGD1307232 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nubpl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CobQ/CobB/MinD/ParA nucleotide binding domain
- binding protein
- septum site-determining protein MinD
- 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family
- NUBPL iron-transfer P-loop NTPase
- protein binding
- cell division ATPase MinD, archaeal
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- flu
- COVID-19
- nuclear type 21 mitochondrial complex I deficiency
- febrile seizure
- Leigh syndrome
- Mitochondrial complex I deficiency
- hereditary disorder
- otitis media
- oxidative phosphorylation disease
- nuclear type 1 mitochondrial complex I deficiency
role in cell
- expression in
- morphology
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nubpl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial respiratory chain complex I assembly
- mitochondrion organization
- iron-sulfur cluster assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- 4 iron, 4 sulfur cluster binding