Ndufv1 Gene Summary [Rat]
Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex I. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 4. Orthologous to human NDUFV1 (NADH:ubiquinone oxidoreductase core subunit V1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndufv1 |
| Official Name | NADH:ubiquinone oxidoreductase core subunit V1 [Source:RGD Symbol;Acc:1359247] |
| Ensembl ID | ENSRNOG00000018117 |
| Bio databases IDs | |
| Aliases | NADH:ubiquinone oxidoreductase core subunit V1 |
| Synonyms | CI-51K, CI-51kD, MC1DN4, MITOCHONDRIAL COMPLEX 1-51KDA subunit, NADH DEHYDROGENASE 51KD, NADH:ubiquinone oxidoreductase core subunit V1, NDUV1, UQOR1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ndufv1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADH-quinone oxidoreductase, F subunit
- NADH-quinone oxidoreductase subunit NuoF
- SLBB domain
- NADH2 dehydrogenase
- enzyme
- protein binding
- NADH2 dehydrogenase (ubiquinone)
- NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
- Respiratory-chain NADH dehydrogenase 51 Kd subunit
Pathways
Biological processes and signaling networks where the Ndufv1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- Huntington disease
- Leigh syndrome
- schizophrenia
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- nuclear type 1 mitochondrial complex I deficiency
- Mitochondrial complex I deficiency
- nuclear type 4 mitochondrial complex I deficiency
- NDUFV1-related disorder
role in cell
- expression in
- phosphorylation in
- growth
- activation in
- production in
- inactivation in
- myogenesis
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- cytosol
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ndufv1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- mitochondrial electron transport, NADH to ubiquinone
- aerobic respiration
- mitochondrial ATP synthesis coupled electron transport
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- respiratory chain complex I
- mitochondrion
- cytosol
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- FMN binding
- NAD binding
- metal ion binding
- NADH dehydrogenase (ubiquinone) activity
- 4 iron, 4 sulfur cluster binding