Zp4 Gene Summary [Rat]
Predicted to enable acrosin binding activity and identical protein binding activity. Predicted to be a structural constituent of egg coat. Predicted to be involved in several processes, including acrosomal vesicle exocytosis; binding activity of sperm to zona pellucida; and negative regulation of binding activity of sperm to zona pellucida. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in collagen-containing extracellular matrix and egg coat. Orthologous to human ZP4 (zona pellucida glycoprotein 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zp4 |
| Official Name | zona pellucida glycoprotein 4 [Source:RGD Symbol;Acc:628708] |
| Ensembl ID | ENSRNOG00000027506 |
| Bio databases IDs | |
| Aliases | zona pellucida glycoprotein 4 |
| Synonyms | ZBP, zona pellucida glycoprotein 4, ZP1, ZP1B, ZPB, ZPB2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zona pellucida-like domain
- Zona pellucida (ZP) domain
- enzyme binding
- extracellular matrix structural constituent
- protein binding
- Trefoil
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
- zona pellucida
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- binding of sperm to zona pellucida
- positive regulation of humoral immune response
- negative regulation of binding of sperm to zona pellucida
- positive regulation of acrosome reaction
- positive regulation of T cell proliferation
- acrosomal vesicle exocytosis
- prevention of polyspermy
Cellular Component
Where in the cell the gene product is active
- egg coat
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- structural constituent of egg coat
- acrosin binding