Tfap2b Gene Summary [Rat]
Enables chromatin binding activity. Involved in response to xenobiotic stimulus. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Char syndrome and patent ductus arteriosus. Orthologous to human TFAP2B (transcription factor AP-2 beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tfap2b |
| Official Name | transcription factor AP-2 beta [Source:RGD Symbol;Acc:1306321] |
| Ensembl ID | ENSRNOG00000011823 |
| Bio databases IDs | |
| Aliases | transcription factor AP-2 beta |
| Synonyms | AP-2B, AP-2beta, AP-2(beta), AP-2(β), AP2-β, E130018K07Rik, PDA2, TCFAP2B, transcription factor AP-2 beta, transcription factor AP-2 β |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tfap2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- Transcription factor AP-2
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- protein homodimerization
- transcription factor activity
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Tfap2b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- open-angle glaucoma
- hereditary disorder
- bladder cancer
- Char syndrome
- overall survival
- craniosynostosis
- non-insulin-dependent diabetes mellitus
- growth failure
- obesity
- patent ductus arteriosus 2
role in cell
- growth
- accumulation in
- binding in
- invasion by
- phosphorylation in
- expression in
- transactivation in
- migration
- proliferation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tfap2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- anatomical structure development
- ductus arteriosus closure
- transcription from RNA polymerase II promoter
- fat cell differentiation
- response to xenobiotic stimulus
- positive regulation of transcription from RNA polymerase II promoter
- glucose metabolic process
- skin development
- positive regulation of neuron apoptotic process
- negative regulation of neuron apoptotic process
- collecting duct development
- negative regulation of transcription from RNA polymerase II promoter
- sympathetic nervous system development
- regulation of insulin secretion
- regulation of cell differentiation
- negative regulation of transcription, DNA-dependent
- kidney development
- positive regulation of transcription, DNA-dependent
- forelimb morphogenesis
- hindlimb morphogenesis
- neuron apoptotic process
- smooth muscle tissue development
- regulation of cell proliferation
- regulation of transcription from RNA polymerase II promoter
- aorta morphogenesis
- negative regulation of apoptotic process
- metanephric nephron development
- retina layer formation
- distal tubule development
- regulation of BMP signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- protein heterodimerization activity