Nmnat2 Gene Summary [Rat]
Predicted to enable nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity; and protein ADP-ribosyltransferase-substrate adaptor activity. Involved in NAD biosynthetic process and cellular response to angiotensin. Predicted to be located in several cellular components, including cytosol; late endosome; and trans-Golgi network. Predicted to be active in Golgi apparatus. Biomarker of hypertrophic cardiomyopathy. Orthologous to human NMNAT2 (nicotinamide nucleotide adenylyltransferase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nmnat2 |
| Official Name | nicotinamide nucleotide adenylyltransferase 2 [Source:RGD Symbol;Acc:1307331] |
| Ensembl ID | ENSRNOG00000027697 |
| Bio databases IDs | |
| Aliases | nicotinamide nucleotide adenylyltransferase 2 |
| Synonyms | AI843915, C1orf15, D030041I09RIK, nicotinamide nucleotide adenylyltransferase 2, PNAT1, PNAT2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nmnat2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nicotinate-nucleotide adenylyltransferase
- nicotinate (nicotinamide) nucleotide adenylyltransferase
- cytidyltransferase-like domain
- protein binding activity, bridging
- enzyme
- nicotinamide-nucleotide adenylyltransferase
- nucleotidyl transferase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- agar
- NAD+
- COX20
- ribosomal protein
disease
- schizophrenia
- ovarian cancer
- systemic lupus erythematosus
- insulin-dependent diabetes mellitus
- neurodegeneration
- hereditary disorder
- spontaneous preterm birth
role in cell
- cell death
- growth
- development
- aggregation in
- polysome loading in
- mono-ADP-ribosylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- extranuclear space
- cellular membrane
- Golgi Apparatus
- cytosol
- synaptic membrane
- Golgi membrane
- trans Golgi network
- synaptic vesicles
- synapse
- late endosomes
- transport vesicles
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nmnat2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleotide biosynthetic process
- NAD biosynthetic process
- negative regulation of cytoplasmic translation
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- trans-Golgi network
- late endosome
- cytosol
- Golgi membrane
- Golgi apparatus
- synapse
- axon
Molecular Function
What the gene product does at the molecular level
- ATP binding
- nicotinate-nucleotide adenylyltransferase activity
- nicotinamide-nucleotide adenylyltransferase activity